DFS

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Double Force Scanning (DFS) is a computational method to predict rescue sites in proteinsIt uses external forces applied to (first-site,second-site) pairs of residues to mimic the effect of a pathogenic mutation (first site) and a candidate rescue mutation (second site). The effect of forces on the protein structure is calculated using the Linear Response Theory combined with the Anisotropic Network Model. The software is available here.

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